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CCR6 inhibitor 35
CAS No. ——
CCR6 inhibitor 35( —— )
Catalog No. M17039 CAS No. ——
CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCCR6 inhibitor 35
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NoteResearch use only, not for human use.
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Brief DescriptionCCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).
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DescriptionCCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6); exhibits potent activity in the migration assay as well as the Gi signal assay with IC50 of <30 nM and 6 nM in human CCR6-transfected CHO cells, respectively, and displays high human CCR6 selectivity over human CCR1 and CCR7; potently inhibits CCR6-dependent cell migration and the increase in ERK phosphorylation in human primary cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight504.528
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Molecular FormulaC24H23F3N4O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-(4-(((1r,4r)-4-((5-(trifluoromethyl)pyridin-2-yl)amino)cyclohexyl)sulfonyl)phenyl)picolinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tawaraishi T, et al. Bioorg Med Chem Lett. 2018 Jul 30. pii: S0960-894X(18)30637-1.
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